【摘要】 目的观察Rho激酶抑制剂对冠状动脉向心性狭窄的变异性心绞痛患者的疗效。方法将34例冠状动脉向心性狭窄的变异性心绞痛患者随机分为治疗组(n=17)和对照组(n=17),2组均给予硝酸酯类、钙离子拮抗剂、阿司匹林、他汀类药物等药物常规治疗,治疗组在此基础上给予Rho激酶抑制剂(盐酸法舒地尔)治疗(法舒地尔60 mg,静脉滴注,每天2次,14 d为1疗程)。2个疗程后比较2组疗效及治疗前后hs-CRP和IL-6水平。结果 2组治疗后hs-CRP、IL-6水平较治疗前明显下降(P<0.05或P<0.01),且治疗组治疗后hs-CRP、IL-6水平明显低于对照组(P均<0.05)。治疗组总有效率稍高于对照组,但差异无统计学意义(P>0.05)。结论 Rho激酶抑制剂对冠状动脉向心性狭窄的变异性心绞痛有较好疗效。其机制可能与抑制炎性因子及冠状动脉痉挛,稳定动脉粥样硬化斑块有关。更多还原

【Abstract】 Objective To observe the effect of Rho-kinase inhibitor—fasudil on variant angina pectoris with coronary arterial concentric stenosis.Methods A total of 34 patients with variant angina pectoris having coronary arterial concentric stenosis confirmed by coronary arterial angiography admitted from January 2007 to June 2010 were enrolled in this report.The patients were randomly divided into treatment group and control group(n=17 each),and basic datas of two groups had comparability.The conventional medication including nitrate,calcium inhibitor,aspirin and statins were taken in two groups,and fasudil hydrochloride(fasudil 60 mg in 250 ml 0.9%NaCl,intravenous infusion,twice a day,14 days as 1 course) was added in treatment group.The therapeutic effect was compared after two courses.Results After treatment the levels of hs-CRP and IL-6 in two groups obviously decreased(P<0.05 or P<0.01),and the levels of hs-CRP and IL-6 in treatment group were markedly lower than those in control group(all P<0.05).The total effective rate in treatment group was higher than that in control group but without a statistical difference(P>0.05).Conclusions Rho-kinase inhibitor,fasudil,has better therapeutic effects on variant angina pectoris with coronary arterial concentric stenosis,and its mechanism is probably associated with inhibiting inflammatory factors and coronary arterial spasm,and stabilizing atherosclerotic plaques.更多还原