【摘要】 目的:调查甘肃省宫颈癌高发区妇女子宫颈上皮内人乳头状瘤病毒(human papillomavirus,HPV)感染状况及其危险因素。方法:采用横断面研究,于2005年在甘肃省陇南市武都区以整群抽样的方法选择30～49岁、有性生活史的农村女性人群进行HPV感染状况调查、宫颈脱落细胞HPV DNA检测及细胞学和病理学诊断。所有女性按年龄分层入组,进行问卷调查、宫颈脱落细胞采集、第二代杂交捕获试验检测HPV。结果:2 052例受检者中,HPV总感染率为7.89%(168/2 052),其中,宫颈正常人群HPV感染率为5.49%(108/1 968),CINⅠ妇女HPV感染率为47.06%(16/34),CINⅡ及以上病变的妇女HPV感染率为78.13%(25/32)。随着宫颈上皮内瘤样病变程度增加,HPV感染率明显上升(χ2=17.996,P<0.001)。HPV感染与丈夫婚外性行为、宫颈柱状上皮异位、尿路感染、阴道滴虫感染等因素有关。结论:武都区30～49岁妇女中HPV感染率为7.89%;随着宫颈上皮内瘤样病变程度的增加,HPV感染率增加;影响HPV感染率的危险因素有丈夫婚外性行为、妇女宫颈柱状上皮异位、尿路感染、阴道滴虫感染等。更多还原

【Abstract】 Objective:To investigate the infection status and risk factors of cervical human papillomavirus(HPV) in women in a high-risk area of cervical cancer in Gansu province.Methods:A cross-sectional study was performed among the rural women aged 30～49 years who have had sexual behaviors in Wudu District,Longnan City,Gansu Province in 2005.Investigation on the infection status of HPV,HPV-DNA test for cervical exfoliated cells,cytological diagnosis and pathological diagnosis were carried out.All the women were divided into different age groups,questionnaire interview,collection of cervical exfoliated cells and HPV detection by Hybrid Capture 2(HC2) were conducted.Results:Among 2 052 women,the total infection rate of HPV was 7.89%(168/2 052),the infection rates of HPV in women with normal cervix,cervical intraepithelial neoplasia(CIN) Ⅰ,CIN Ⅱ and above lesions were 5.49%(108/1 968),47.06%(16/34) and 78.13%(25/32),respectively.With the aggravation of CIN,the infection rate of HPV increased significantly(χ2=17.996,P<0.001).HPV infection was related to extramarital sexual behaviors of their husbands,columnar ectopy,urinary tract infection and vaginal trichomoniasis infection.Conclusion:The infection rate of HPV in women aged 30～49 years in Wudu District is 7.89%;with the aggravation of CIN,the infection rate of HPV increases;the risk factors affecting HPV infection rate include extramarital sexual behaviors of their husbands,columnar ectopy,urinary tract infection and vaginal trichomoniasis infection.更多还原