【摘要】 目的:了解云南三边境州10个特有少数民族的7岁以下儿童血红蛋白病和G6PD缺乏症的现状。方法:血红蛋白病检测:对调查者应用日本SysmexKX-21N和迈瑞-2000血细胞分析仪进行血细胞分析,醋酸纤维薄膜电泳检测血红蛋白,DNA序列分析及ARMS基因检测;G6PD缺乏症检测采用改良葡萄糖6-磷酸脱氢酶(G6PD)比值法。结果:地贫检出率以德宏州最高(46.2%),怒江州最低(30.6%),版纳州居中。β-地贫以阿昌族居首位40.6%(39/96),独龙族最低为2.5%(5/204)。α-地贫以版纳傣族最高为22.1%(266/1 204),其次为独龙族19.1%(39/204)。G6PD缺乏症检出率德宏州为6.7%(146/2 190),版纳州为2.2%(60/2 780),怒江州为1.0%(14/1 407)。G6PD缺乏症以德昂族最高为8.6%(30/349),其次为阿昌族7.3%(19/261)。异常血红蛋白检出率为2.4%。结论:血红蛋白病和G6PD缺乏症在云南省三边境州10个特有少数民族7岁以下儿童属高发,血红蛋白病和G6PD缺乏症的人群地理分布与历史上疟疾流行的地理分布存在着一定的相关性。更多还原

【Abstract】 Objective:To understand the current situations of hemoglobinopathy and G6PD deficiency among the children under 7 years of ten ethnic groups in border of Yunnan.Methods:Detection of hemoglobin: the children received blood cell analysis by Japanese SysmexKX-21N blood cell analyzer and Mindray-2000 blood cell analyzer,cellulose acetate membrane electrophoresis was used to detect hemoglobin,DNA sequence analysis and ARMS gene detection were conducted.Detection of G6PD deficiency: modified G6PD ratio method was used.Results:The incidence of thalassaemia in Dehong prefecture was the highest(46.2%),the incidence of thalassaemia in Nujiang prefecture was the lowest(30.6%),the incidence of thalassaemia in Banna prefecture was moderate.The incidence of β-thalassaemia in children of Achang nationality was the highest(40.6%,39/96),the incidence of β-thalassaemia in children of Dulong nationality was the lowest(2.5%,5/204).The incidence of α-thalassaemia in children of Dai nationality was the highest(22.1%,266/1 204),followed by the children of Dulong nationality(19.1%,39/204).The detection rates of G6PD deficiency in Dehong prefecture,Banna prefecture and Nujiang prefecture were 6.7%(146/2 190),2.2%(60/2 780) and 1.0%(14/1 407),respectively.The detection rate of G6PD deficiency in children of Deang nationality was the highest(8.6%,30/349),followed by the children of Achang nationality(7.3%,19/261).The detection rate of abnormal hemoglobin was 2.4%.Conclusion:The incidences of hemoglobinopathy and G6PD deficiency are high among the children under 7 years of ten ethnic groups in Yunnan,there is a certain correlation between the population distribution and regional distribution of hemoglobinopathy and G6PD deficiency and geographical distribution of malaria prevalence in history.更多还原