【摘要】 目的:探讨MIF基因-173位点G/C多态性与子宫内膜异位症的遗传易感性的相关性。方法:应用聚合酶链反应-限制性片断长度多态性技术(PCR-RFLP分析技术)检测广东籍汉族生育期妇女子宫内膜异位症患者49例(内异症组)和非子宫内膜异位症者49例(对照组)的MIF基因-173位点G/C单核苷酸多态性。结果:①内异症组MIF基因-173位点GG、GC、CC 3种基因型分布频率分别为53.06%、34.69%、12.25%;对照组MIF基因-173位点GG、GC、CC 3种基因型的分布频率分别为61.23%、32.65%、6.12%,两组间基因型的分布频率比较差异无统计学意义(P>0.05)。②MIF基因-173位点G、C等位基因型在内异症组中的分布频率分别为70.41%、29.59%,在对照组中分别为77.55%、22.45%,两组间等位基因型频率比较差异无统计学意义(P>0.05)。结论:MIF基因-173位点G/C多态性可能与广东汉族妇女人群子宫内膜异位症的遗传易感性无关。更多还原

【Abstract】 Objective:To explore the correlation between G/C polymorphism of-173 locus in macrophage migration inhibitory factor(MIF) gene and hereditary susceptibility of endometriosis. Methods:PCR-PFLP technique was used to detect G/C single nucleotide polymorphisms of-173 locus in MIF gene of 49 women of childbearing age with endometriosis(endometriosis group) and 49 women without endometriosis(control group) of Han nationality in Guangdong. Results:In endometriosis group,the distribution frequencies of GG genotype,GC genotype and CC genotype of-173 locus in MIF gene were 53.06%,34.69% and 12.25%,respectively;in control group,the distribution frequencies of GG genotype,GC genotype and CC genotype of-173 locus in MIF gene were 61.23%,32.65% and 6.12%,respectively,there was no significant difference between the two groups(P>0.05).The distribution frequencies of G allele and C allele of-173 locus in MIF gene were 70.41% and 29.59% in endometriosis group,77.55% and 22.45% in control group,respectively,there was no significant difference between the two groups(P>0.05). Conclusion:G/C polymorphism of-173 locus in MIF gene may be independent of hereditary susceptibility of endometriosis in Han women in Guangdong.更多还原