【摘要】 目的:评价子宫内膜异位症合并不孕患者腹腔液TNF-α与IL-6水平与不孕的相关性。方法:选取60例因不孕或盆腔痛就诊的患者,其中包含有40例合并不孕的内异症患者和20例有成功生育史的盆腔痛的内异症患者。在腹腔镜手术之前抽吸腹腔液,通过酶联免疫吸收法检测TNF-α与IL-6水平,通过统计学分析评价TNF-α与IL-6与EM所致不孕的相关性。结果:TNF-α与IL-6水平与内异症的rAFS分期没有相关性,但在不孕EM患者中水平比单纯盆腔痛患者水平显著性增高(p<0.05),说明在内异症导致的不孕中TNF-α与IL-6可能发挥了一定的作用。结论:腹腔液中的TNF-α与IL-6可能参与了EM相关性不孕的病理过程。更多还原

【Abstract】 Objective:To evaluate the correlation between TNF-α and IL-6 levels in peritoneal fluid and infertility in patients with endometriosis combined with infertility.Methods:60 patients with infertility or pelvic pain were selected,including 40 patients with endometriosis combined with infertility and 20 patients(with the history of successful birth) with endometriosis combined with pelvic pain.The peritoneal fluid was aspirated before laparoscopic surgery,ELISA was used to detect the levels of TNF-α and IL-6,the correlation between TNF-α,IL-6 and infertility induced by endometriosis was analyzed statistically.Results:There was no correlation between TNF-α and IL-6 levels and rAFS stages of endometriosis.However,the levels of TNF-α and IL-6 in infertile patients with endometriosis were significantly higher than those in patients with simple pelvic pain(P<0.05),TNF-α and IL-6 might play certain roles in the pathogenesis of infertility induced by endometriosis.Conclusion:TNF-α and IL-6 in peritoneal fluid may participate in the pathogenesis of endometriosis-related infertility.更多还原