【摘要】 目的:了解育龄妇女血液叶酸水平,为制定叶酸预防出生缺陷方案提供依据。方法:取163名育龄妇女空腹静脉血4 m l,用电化学发光方法测定血清叶酸和红细胞叶酸水平。结果:血清叶酸和红细胞叶酸的平均水平分别为(9.71±4.16)ng/L和(529.18±194.25)ng/L,缺乏率分别为11.04%和1.23%。分别有53.99%和58.28%的妇女血清叶酸、红细胞叶酸水平小于预防神经管畸形最佳浓度,农村育龄妇女高达74.51%。结论:云南省育龄妇女叶酸缺乏率不高,但有1/2妇女血液叶酸水平小于预防神经管畸形最佳浓度,孕前应结合改变膳食结构健康教育加强叶酸的补充,并重点关注农村育龄妇女。更多还原

【Abstract】 Objective:To characterize the level of blood folate among reproductive women and to provide information for carrying out supplying folic acid to prevent birth defects.Methods:4ml venous blood was drawn for each of 163 reproductive women and serum and red cell folate concentrations were detected with electrochemiluminescence immunoassay method.Results:The average level of serum folate was(9.71±4.16) ng/L and red cell folate was(529.18±194.25)ng/L.The deficient rates of serum folate and red cell folate was 11.04% and 1.23% respectively.Above half(Serum 53.99%,RBC 58.28%)of women was serum folate and red cell folate levels lower than the optimal level for the prevention of folate-responsive neural tube defects,and the rate of rural women were as high as 74.51%.Conclusion:Although not so many women are blood folate deficient,half of them have lower blood folate levels than the optimal level for the prevention of NTDs.Dietary modification and supply folic acid should be integrated and special attention should be paid to women living in rural areas.更多还原