【摘要】 目的:探讨川崎病(KD)患儿发生冠状动脉病变(CAL)的危险因素。方法:回顾性分析1998年～2008年吉林省553例住院KD患儿的临床资料,对12种可能与CAL发生的相关临床因素进行相关性和非条件Logistic回归分析。结果:发病年龄、血浆白蛋白降低与冠状动脉病变有相关性(P<0.05),Logistic多因素非条件回归分析结果表明,发病年龄(X1)的OR值为1.125,95%CI:1.046～1.211,P<0.01,血浆白蛋白<30g/L(X2)的OR值为1.583,95%CI:1.079～2.322,P<0.05。通过比较两个变量的标准化回归系数绝对值,可知血浆白蛋对CAL发生贡献大一些,CAL与患儿年龄呈负相关。结论:发病年龄、血浆白蛋白降低是KD患儿发生CAL的危险因素。更多还原

【Abstract】 Objective:To explore the risk factors of coronary artery lesion(CAL) caused by Kawasaki disease(KD).Methods:The clinical data of 553 children with KD from the hospital from 1998 to 2008 were analyzed retrospectively,12 probable clinical factors related to the occurrence of CAL were analyzed by correlation analysis and unconditional logistic regression analysis.Results:There was correlation between onset age,the decrease of plasma albumin and CAL(P<0.05),multivariate unconditional logistic regression analysis showed that the OR values of onset age and plasma albumin<30 g/L were 1.125(95% CI =1.046~1.211,P<0.01) and 1.583(95% CI= 1.079~2.322,P<0.05),respectively.Plasma albumin more contributed to the occurrence of CAL by comparing the standardized regression coefficient absolute values of the two variables,there was a negative correlation between CAL and onset age.Conclusion:Onset age and decrease of plasma albumin are the risk factors of CAL in children with KD.更多还原