【摘要】 目的:通过测定妊娠期糖尿病(GDM)脐血脂联素、胰岛素、C肽、糖化血红蛋白水平,探讨GDM对胎儿代谢水平的影响。方法:采用放射免疫法测定30例GDM患者及26例正常孕妇脐血脂联素、胰岛素、C肽水平,采用乳胶增强的免疫竞争抑制法测定脐血糖化血红蛋白水平。结果:GDM组脐血脂联素水平为(20.74±5.66)μg/ml,明显低于对照组(26.66±8.43)μg/ml,脐血胰岛素、糖化血红蛋白水平分别为(31.53±14.63)uIU/ml,(4.9±0.7)%,明显高于对照组,差异有统计学意义。两组脐血脂联素水平与脐血胰岛素、糖化血红蛋白呈明显负相关。结论:宫内暴露于GDM不良环境因素下可引起胎儿脂联素水平的下降及胰岛素、C肽、糖化血红蛋白水平的升高。胎儿代谢水平的改变影响了胎儿的生长发育,还可能与将来子代的代谢性疾病具有相关性。更多还原

【Abstract】 Objective:To explore the effect of gestational diabetes mellitus(GDM) on fetal metabolism level by detecting the levels of adiponectin,insulin,C-peptide and glycosylated hemoglobin in umbilical cord blood.Methods:Radioimmunoassay was used to detect the levels of adiponectin,insulin and C-peptide in umbilical cord blood of 30 cases with GDM and 26 normal pregnant women,latex enhanced immunosuppression competition method was used to detect the level of glycosylated hemoglobin in umbilical cord blood.Results:The level of adiponectin in umbilical cord blood in GDM group was(20.74±5.66) μg/ml,which was significantly lower than that in control group [(26.66±8.43) μg/ml],the levels of insulin and glycosylated hemoglobin in umbilical cord blood in GDM group were(31.53±14.63) uIU/ml and(4.9±0.7)%,respectively,which were significantly higher than those in control group;there was negative correlation between adiponectin level and insulin,glycosylated hemoglobin levels in umbilical cord blood in the two groups.Conclusion:Exposure to bad environment of GDM in uterus may cause the decrease of fetal adiponectin level and the increases of insulin,C-peptide and glycosylated hemoglobin;the changes of fetal metabolic level affect the growth and development of fetuses,which may be related to metabolic diseases of offsprings.更多还原