【摘要】 目的探讨人工肝对慢性重型肝炎肝衰竭远期预后的影响。方法回顾性分析199例慢性乙型重型肝炎患者,分为人工肝治疗组101例和内科治疗对照组98例,随访3年内患者肝功能CTP分级及存亡状态,两组之间构成比的比较采用χ2检验,采用Kaplan-Meier方法进行生存分析,生存率比较采用Log-Rank检验。结果不同治疗组肝功能分级的构成比只有半年时差异有统计学意义(χ2=8.358,P=0.015)。治疗后1、2、3年时的差异均无统计学意义。治疗组3年生存率高于对照组,差异有统计学意义(χ2=3.840,P=0.050)。结论人工肝对促进慢性重型肝炎近期恢复疗效确切,对远期肝功能演变无明显影响,但可显著提高慢性重型肝炎患者的远期生存率。更多还原

【Abstract】 Objective To assess the effect of artificial liver on the long-term prognosis of hepatic failure caused by chronic hepatitis gravis.Methods A retrospective analysis was made among 199 cases of chronic hepatitis B gravis,which were divided into the treatment group(artificial liver,101 cases) and the control group(conventional medical treatment,98 cases),with a three-year follow-up of liver function CTP grading and survival condition.χ2 test was taken to make a comparison in constituent ratio between the two groups and Kaplan-Meier method was adopted to make an analysis of survival condition,comparing survival rate with Log-Rank test.Results There was a significant difference in constituent ratio of liver function grading between the two groups(χ2=8.358,P=0.015) only at the middle of a year,with no significant difference at one year,two years and three years after the treatment.Three-year survival rate in the treatment group was higher than that in the control group,with significant difference(χ2=3.840,P=0.050).Conclusion Artificial liver is quite a help to the short-term recovery from chronic hepatitis gravis,with a reliable curative effect,and brings about little effect on long-term development of the liver function.But it can remarkably prolong the long-term survival time of those with chronic hepatitis B gravis.更多还原