【摘要】 目的探讨nm23-H1、NGAL在宫颈癌中的表达与预后的关系。方法应用免疫组化SABC法检测100例宫颈癌中nm23-H1、NGAL的表达。结果宫颈癌中nm23-H1、NGAL的阳性率分别为48%和61%。其中,nm23-H1在不同年龄分组、临床分期和病例类型中阳性表达率差异无统计学意义(P>0.05);在有肿瘤转移的标本中阳性率为67.86%,低分化标本中阳性率为76.19%,肿瘤直径≥4cm标本中阳性率表达率56.52%,差异有统计学意义(P<0.05)。NGAL在不同临床分期和不同肿瘤直径组中阳性表达率无统计学意义(P>0.05);>45岁组标本中阳性率为70.49%,在鳞癌标本中阳性率为70.00%,在发生肿瘤转移的标本中阳性率为82.14%,在中高分化标本中阳性率为67.09%,差异有统计学意义(P<0.05)。结论 nm23-H1和NGAL的表达情况对宫颈癌的预后评估有一定的意义。更多还原

【Abstract】 Objective To investigate the expression of nm23-H1 and NGAL gene in cervical cancer and its effect on the development of the cervical cancer.Methods The expression of nm23-H1,NGAL gene in 100 cases cervical cancer were studied with SABC immunohistochemcal technique.Results In cervical cancer,the positive expression rate of nm23-H1 and NGAL were 48% and 61%.The positive expression rate of nm23-H1 have no differences in different age groups,clinical stage and type of cases(P>0.05).The positive expression rate of nm23-H1 in the tumor metastasis,poor differentiation and tumor diameter ≥ 4cm specimens are high positive expression rate,respectively,67.86%,76.19% and 56.52%,the difference in their respective groups was significant(P<0.05).There were no differences in positive expression rate in different clinical stages and different tumor size groups of NGAL(P>0.05).NGAL have more positive expression rate in >45-year-old group,squamous cell carcinoma,tumor metastasis,high differentiation and tumor diameter ≥4cm specimens,respectively,70.49%,70.00%,82.14% and 67.09%,the difference in their respective groups were significant(P<0.05).Conclusion The positive expression rate of nm23-H1 and NGAL in the prognosis of cervical cancer have a certain significance.更多还原