【摘要】 目的探讨联合应用抗结核中西药和免疫调节剂对糖尿病合并肺结核患者免疫功能、痰菌阴转率、空洞闭合率及其临床疗效。方法将87例糖尿病合并肺结核患者分为对照组(44例)和治疗组(43例),对照组采用控制饮食、口服降糖药物的方法及2S(E)HRZ/4H3R3的化疗方案进行治疗;治疗组强化期上加服结核丸及免疫调节剂给予母牛分支杆菌菌苗,抗结核治疗2个月、6个月后对痰菌情况及空洞闭合情况进行对比分析,记录治疗前后T细胞亚群变化情况及其临床疗效。结果治疗后治疗组与对照组比较,CD4治疗后较治疗前明显上升(P<0.05),CD8治疗后较治疗前明显下降(P<0.05),CD4/CD8治疗后较治疗前明显上升(P<0.05);痰菌转阴率比较:对照组和治疗组2个月末痰菌转阴率分别为61.36%和81.40%,与对照组比较存在显著性差异(P<0.05),治疗6个月末治疗组和对照组分别为75.00%和93.02%,与对照组比较存在显著性差异(P<0.05);空洞闭合率比较,与对照组比较无显著性差异(P>0.05);临床疗效比较:疗程结束后,两组的总有效率分别为81.82%和95.35%,与对照组比较有显著性差异(P<0.05)。结论结核丸联合抗结核药治疗糖尿病合并肺结核疗效显著,值得临床推广。更多还原

【Abstract】 objective To investigate the immune function,sputum conversion rate,closure rate of pore and the clinical efficacy of Chinese and western medicine combined with immunomodulation on diabetes with pulmonary tuberculosis(DPT).Methods Eighty-seven cases of DPT were randomly divided into treatment group(43 cases)and control group(44 cases).The control group received diet control,oral antidiabetic drug and the 2S(E)HRZ/4H3R3 chemotherapy regimen.The treatment group was given tuberculosis pills and immunomodifier on the base of the control group.After 2-and 6-month treatment in hospital,the sputum conversion rate,closure rate of pore,T lymphocyte subgroups and the clinical efficacy were analyzed.Results After therapy,CD8 was increased and CD4and CD4/CD8 were decreased remarkably in the treatment group compared with the control group(P<0.05).After 2-month therapy,the sputum conversion rates of the two groups were 61.36% and 81.40%,respectively.After 6-month therapy,the sputum conversion rates of the two groups were 75.00%and 93.02%,respectively,with a significant difference between the two groups(P<0.05)and no significant difference in the closure rates of pore between the two groups(P>0.05).When treatment was finished,the total effective rates of the two groups were 1.82% and 95.35% respectively,with a significant difference between the two groups(P<0.05).Conclusion The therapy regimen(Chinese and western medicine combined with immunomodulation)shows an obvious effect on DPT,worthy to be popularized.更多还原