【摘要】 目的探讨2型糖尿病肾病患者血清C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)和白细胞介素-8(IL-8)水平的变化及意义。方法收集80例2型糖尿病患者,根据尿白蛋白排泄率(UAER)分为无白蛋白尿组(DM组)21例,早期糖尿病肾病患者28例(DN1组),临床糖尿病肾病患者31例(DN2组),另选20例健康体检者作为对照(对照组)。测定各组血清CRP、TNF-α、IL-6和IL-8水平并进行统计学分析。结果 2型糖尿病肾病患者组血清中CRP、TNF-α、IL-6和IL-8水平高于正常人组及DM组,随着糖尿病肾病病情的加重而逐渐增高,组间比较差异有显著性(P<0.05)。结论 CRP、TNF-α、IL-6和IL-8作为重要的炎症介质参与了DN的病理生理过程,在DN的发生及发展过程中可能起重要作用。检测CRP、TNF-α、IL-6和IL-8有助于DN患者病情及预后的判断。更多还原

【Abstract】 Objective To investigate the changes of serum CRP,TNF-α,IL-6 and IL-8 levels in patients diabetic nephritis and the clinical significance.Methods 80 patients with type 2 diabetes were selected for this study.The patients were divided into three groups according to urinary albumin excretion rate(UAER): 21 patients with normal UAER were DM group.28 patients with microalbuminuria and 31 patients with clinical protein.20 healthy subjects were used as control group.The serum levels of CRP、TNF-αIL-6 and IL-8 were measured.Results Serum levels of CRP、TNF-αIL-6 and IL-8 were significantly higher in patients with diabetic nephropathy than those in controls(P <0.05).Conclusion CRP,TNF-α,IL-6 and IL-8 participated in the pathogenesis of diabetic nephropathy.Monitoring the changes of their serum levels was helpful for the management of the disease.and probably be a prognostic factor of DN.更多还原