【摘要】 基于对血管抑素和内皮抑素作用下肿瘤抗血管生成及血液动力学的数学建模与数值模拟,研究抗血管生成治疗对肿瘤微血管网的影响及对微环境流动的改善作用.研究表明,抗血管生成治疗后:1)新生血管的生长与分叉受到抑制,血管化程度降低;2)血液灌注量减少,间质高压得到缓解,渗入宿主组织的间质液减少,负向跨壁流量大幅下降.更多还原

【Abstract】 The effects of anti-angiogenesis treatment by angiostain and endostatin on normalization of tumor microvasculature and microenvironment was investigated,based on mathematical modeling and numerical simulation of tumor anti-angiogenesis and tumor haemodynamics.The results show that,after anti-angiogenesis treatment: 1) the proliferation,growth and branching of neo-vessels is effectively inhibited,the extent of vascularization in tumors is accordingly reduced;2) the overall blood perfusion inside tumor is declined;the plateau of tumor interstitial fluid pressure is relieved;the interstitial fluid oozing out from the tumor periphery into the surrounding normal tissue is reduced;the intravasations across vasculature is remarkably decreased.更多还原