【摘要】 目的:了解依那西普治疗强直性脊柱炎(AS)时对肝功能的影响。方法:分析2例AS患者用药后引起丙氨酸氨基转移酶异常改变的情况。结果:2例患者均因强直性脊柱炎皮下注射依那西普1～2周后引起丙氨酸氨基转移酶升高,经保肝治疗2～4周后肝功恢复正常。结论:依那西普(益赛普)能抑制可溶性肿瘤坏死因子(TNF)的活性,调节炎症反应过程,用于早期及活动性AS患者的治疗。在使用依那西普治疗过程中可引起丙氨酸氨基转移酶升高,经保肝治疗后肝功可恢复正常。更多还原

【Abstract】 OBJECTIVE: To investigate the effect of etanercept on liver function in patients with ankylosing spondylitis(AS).METHODS: We analyzed two patients whose alanine aminotransferase(ALT) level showed abnormal change after treatment with etanercept.RESULTS: The ALT level in the two AS patients elevated after 1-2 weeks’ treatment with etanercept,but which returned to normal after 2-4 weeks’ treatment with liver-protecting agents.CONCLUSION: Etanercept can be applied to treat early active AS by inhibiting the activity of soluble tumor necrosis factor(TNF) and regulating the process of inflammation reaction.Etanercept might result in ALT elevation but which could return to normal after treatment with liver-protecting agent.更多还原