【摘要】 采用荧光光谱、差热扫描和核磁共振法研究了不同酸度和温度下β-环糊精(β-CD)、羟丙基-β-环糊精(HP-β-CD)和磺丁醚-β-环糊精(SBE-β-CD)对氯诺昔康(LX)的包合特性。结果表明,3种环糊精与氯诺昔康均形成1∶1的包合物。以包合常数作为包合稳定性的量度,包合稳定性为SBE-β-CD>HP-β-CD>β-CD。更多还原

【Abstract】 The inclusions of lornoxicam(LX) by β-cyclodextrin(β-CD),hydroxypropyl-β-cyclodextrin(HP-β-CD),and sulfobutyl ether-β-cyclodextrin(SBE-β-CD) were studied by fluorescence spectroscopy,differential scanning calorimetry(DSC) and NMR at different pH and temperature.The results showed that the 1∶ 1 inclusion compounds were formed between lornoxicam and CDs.Based on the formation constants,the interactions between lornoxicam and the three CDs follow an order of SBE-β-CD>HP-β-CD>β-CD.更多还原