【摘要】 以手性联二萘酚为原料,合成了3,3’位取代的手性联二萘酚衍生物,研究了该衍生物配体在二乙基锌存在下,催化苯乙炔与苯甲醛的不对称加成反应,产物的产率为73%,e.e.值为40%。研究结果表明,手性联二萘酚衍生物结构的微小变化导致催化产物构型的改变。更多还原

【Abstract】 Chiral 3,3’-substituted 1,1’-bi-2-napthol(BINOL) derivatives were synthesized from BINOL.The asymmetric addition of phenylacetylene and benzaldehyde in the presence of the BINOL derivative and diethyl zinc afforded the corresponding propargylic alcohols with 73% yield and 40% enatiomeric excess.更多还原