【摘要】 苍耳子(Fructus Xanthii)是常用中药,主要用于慢性鼻炎的治疗,有一定的毒性.为明确苍耳子产生生物活性的物质基础,通过溶剂萃取、正、反相反复硅胶柱色谱及MCI柱色谱等方法,对苍耳子80%甲醇提取物进行分离纯化,用质谱、核磁共振谱等方法进行结构鉴定.从正丁醇萃取物中分离鉴定7个化合物:阿魏酸(1)、咖啡酸(2)、绿原酸(3)、4-O-咖啡酰奎宁酸甲酯(4)、6,7-二甲基-1,4-二氢-2,3-喹喔啉二酮(5)、咖啡酸胆碱酯(6)和4′-O-二氢红花菜豆酸钠盐-β-D-葡萄糖苷(7).其中,化合物4~7为首次从该植物中分离得到.图1参10更多还原

【Abstract】 Cang Er Zhi(Fructus Xanthii),from the fruit of Xanthium sibiricum Patr.,is a commonly used traditional Chinese medicine for chronic rhinitis with a little toxicity.In order to prove the material of X.sibiricum that produce bioactivities,it is necessary to investigate its chemical constituents.Solvent extraction,repeated column chromatography on silica,C-18 and MCI were used for isolating compounds from the 80% MeOH/H2O extract of X.sibiricum,and MS and NMR spectral evidences were used for structure elucidation.Seven compounds were isolated: Ferulic acid(1),caffeic acid(2),chlorogenic acid(3),4-O-caffeoyl quinic acid methyl ester(4),N-(1′-D-deoxyxylitolyl)-6,7-dimethyl-1,4-dihydro-2,3-quinoxalinedione(5),caffeic acid choline ester(6) and dihydrophaseic acid sodium salt 4′-O-β-D-glucopyranoside(7).Among of them,compounds 4~7 were isolated from X.sibiricum for the first time.Fig1,Ref 10更多还原