【摘要】 目的:探讨食管癌患者单纯超分割放射治疗与常规放疗生存率及影响。方法:将65例食管鳞癌患者随机分成两组,常规放疗组39例,常规分割,5次/周,1次/d,2 Gy/次,总剂量为70 Gy/7周;超分割放疗组26例,5次/周,2次/d,1.3 Gy/次,2次治疗间隔6 h,总剂量为65 Gy/5周。全部病例均采用GWGP80型钴-60远距离治疗机体外照射。结果:常规放疗组和超分割放疗组的1、3年生存率分别为46.1%、20.5%和61.5%、42.3%。超分割放疗组明显优于常规放疗组,两组比较,差异有高度统计学意义(P<0.01)。病变长度3～5 cm、蕈伞型预后好。两组患者放疗副作用比较,差异无统计学意义(P>0.05)。结论:全程超分割放疗(5次/周,1.3 Gy/次,2次/d,间隔6 h,总剂量为65 Gy/5周)能明显提高食管癌患者的生存率。更多还原

【Abstract】 Objective: To study the survival rate and effect of esophageal cancer patients treated by pure hyperfractioned radiotherapy and conventional radiotherapy.Methods: 65 cases of patients with esophageal squamous cell carcinoma were randomly divided into two groups,39 cases of conventional radiotherapy using conventional fractionation 5 fractions per week,1 fraction per day,2 Gy per fraction to total dose 70 Gy on 7 weeks;hyperfractioned radiation therapy group 26 cas-es,5 fractions per week,2 fractions per day with 6 hours between two fractions,1.3 Gy per fraction to total dose 65 Gy on 5 weeks.All cases were treated with external beam radiotherapy by GWGP80 Co-60 cobalt teletherapy machine.Results: 1-year and 3-years survival rat of conventional radiotherapy and hyperfractioned radiotherapy group were 46.1%,20.5% and 61.5%,42.3% separately.Hyperfractioned group was significantly batter than the conventional group,there were sig-nificant differences in the two groups(P<0.01).Lesion length of 3-5 cm of fungating tupe had a good prognosis.There was no significant difference of radiotherapy toxity between the two groups(P>0.05).Conclusion: Hyperfractioned radiation therapy(5 fractions per week,1.3 Gy per fraction,2 fractions per day with 6 hours interval to total dose 65 Gy over 5 weeks) could sificantly improve the survival rate.更多还原