【摘要】 目的:探讨溃疡性结肠炎(UC)缓解期血清TNF-α水平与复发的相关性及三七预防复发的作用。方法:选取我院UC缓解期患者60例,检测其血清TNF-α值,并以30例健康受试者为正常对照。60例患者随机分为试验组和对照组,每组各30例。对照组采用柳氮磺胺嘧啶治疗,试验组联合中药三七治疗,3个月后统计复发情况。结果:试验组与对照组的血清TNF-α值分别为(18.5±9.6)pg/ml和(8.8±5.3)pg/ml,两组比较差异有高度统计学意义(P<0.01);TNF-α高表达组与低表达组的复发率分别为35.29%和11.54%(P<0.05);TNF-α水平复发组与未复发组分别为(26.3±8.7)pg/ml和(14.7±7.4)pg/ml(P<0.05);试验组与对照组复发率分别为13.33%和36.67%,两组比较差异有统计学意义(P<0.05)。结论:缓解期UC患者的血清TNF-α水平与其后一定时间内的复发率呈正相关,可作为UC缓解期的监测指标,中药三七具有预防UC复发的作用。更多还原

【Abstract】 Objective:To observe the correlation of TNF-α levels in remission and the preventive effect of Panax Notoginseng on reactivation in patients with ulcerative colitis.Methods:TNF-a levels in plasma were detected in 60 patients who with ulcerative colitis in remission,and 30 normal persons were collected as control group.These patients were randomly classified into treatment group(n=30) and control group(n=30).Relapse rate was inspected after 3 months’ treatment.Results:The TNF-α levels in treatment group were significantly higher than those of control group [(18.5±9.6) pg/ml and(8.8±5.3) pg/ml](P<0.01),the relapse rate of high expression of TNF-α was higher than that of low expression of TNF-α(35.29% and 11.54%)(P<0.05),the relapse rate in treatment group was obviously lower than that in control group(13.33% and 36.67%)(P<0.05).Conclusion:The relapse rate of ulcerative colitis is correlated to the TNF-α levels.Panax Notoginseng can reduce the occurrence of Ulcerative Colitis.更多还原