【摘要】 目的:观察苦参素胶囊联合阿德福韦酯治疗HBeAg阳性慢性乙型肝炎(CHB)的临床效果。方法:选择HBsAg、HBeAg、HBV DNA持续阳性半年以上,HBV DNA≥1.0×105 copies/ml,ALT大于正常上限2倍以上,TBil升高小于正常上限3倍的CHB患者104例,随机分为两组,对照组50例,给予阿德福韦酯胶囊10 mg,1次/d,口服。治疗组54例,在对照组基础上给予苦参素胶囊0.3,3次/d,口服。两组对症治疗措施相似,均不用其他抗病毒、免疫调节及抗肝纤维化制剂,疗程共9个月。观察肝功能(ALT、TBil)、乙肝病毒指标(HBsAg、HBeAg、HBV DNA)及肝纤维化指标(HA、LN、ⅣC)的变化。结果:治疗组肝功能复常率、乙肝病毒指标阴转率均高于对照组。两组比较差异有统计学意义(P<0.05)。肝纤维化指标两组治疗前比较,差异无统计学意义(P>0.05);治疗组治疗后与对照组比较差异有统计学意义(P<0.01),与治疗前比较差异有高度统计学意义(P<0.01)。结论:苦参素胶囊联合阿德福韦酯治疗HBeAg阳性CHB患者,在肝功能复常、乙肝病毒指标阴转及肝纤维化指标改善方面均有显著作用。更多还原

【Abstract】 Objective: To observe the clinical effects of Kurorinone Capsule combined Adefovir Dipivoxil Capsule in treating of patients with HBeAg positive chronic hepatitis B(CHB).Methods: To choose 104 CHB patients with HbsAg,HbeAg,HBV DNA remaining positive for more than six months,HBV DNA?Y1.0×105 copies/ml,ALT was more than 2 times upper limit of normal,TBil increased less than 3 times upper limit of normal.These patients were randomly divided into two groups,50 patients of the control group were given with Adefovir Dipivoxil Capsule,10 mg,1 time/d,oral route.On the basis of the treatment of the control group,54 patients of the treatment group were given with Kurorinone capsule 0.3,3 times/d,oral route.Symptomatic treatment measures were similar of the two groups,other anti-virus,immunity adjusting and Anti-hepatic fibrosis preparation were not used in both groups.The period of treatment was 9 months.Observing the changes of liver function(ALT,TBil),hepatitis B virus indicator(HBsAg,HBeAg,HBV DNA) and liver fibrosis indicator(HA,LN,￠?C).Results: The recovery rate of liver function and the sputum negative conversion rate of hepatitis B virus indicator of the treatment group both were greater than those of the control group.There was a statistical significance between the two groups(P<0.05);the difference had no statistical significance to compare liver fibrosis indicator of two groups before treatment(P￡?0.05);the difference had a statistical significance to compare the treatment group with the control group after the treatment(P<0.01),the difference had a statistical significance to compare the treatment group after the treatment with the treatment group before the treatment(P<0.01).Conclusion: Kurorinone Capsule combined with Adefovir Dipivoxil Capsule in treating patients with HBeAg positive chronic hepatitis B has notable effects in the recovery of liver function,the sputum negative conversion of hepatitis B virus and the liver fibrosis indicator improvement.更多还原