【摘要】 目前大量的研究证明,HBV感染是引起原发性肝癌的主要原因。核因子κB(NFκ-B)的发现,在炎症和肿瘤之间搭起了一座桥梁。HBV通过自身直接或者间接引起NFκ-B的激活,NFκ-B又作用于致癌因子,从而引发肿瘤。但这种相互作用不是单向的,而是级联放大的负反馈。NFκ-B不仅参与肝癌的发生、发展,还与化疗药物耐药有关,NFκ-B在HBV感染引起的肝癌中的作用至关重要。更多还原

【Abstract】 It has been proved that hepatitis B virus infection is the main factor causing hepatocellular carcinoma(HCC).The discovery of NF-κB set up a bridge between inflammation and tumor.NF-κB is activated by hepatitis B virus directly or indirectly,which then results in cancer by acting on carcinogens.The interaction is a negative feedback which is cascade amplified rather than unidirectional.Not only did NF-κB take part in the development in cancer,but also primary drug resistance.NF-κB plays a rather important role in HBV infection related hepatocellular carcinoma.The HBV-NF-κB-HCC clues will be reviewed in this article.更多还原