【摘要】 脂肪组织除了调节能量储存和营养平衡,还是一个活跃的内分泌器官,它释放出大量的蛋白激素(脂肪因子)作用于肝脏、骨骼肌、大脑等部位,从而实现对止血、血压、糖脂代谢、炎症、动脉粥样硬化等生理活动的调节。已有报道脂联素、瘦素、网膜素、内脂素、丝氨酸蛋白酶抑制剂等具有胰岛素增敏剂的作用;然而,其他一些脂肪因子,如chem erin、抵抗素、视黄醇结合蛋白4、肿瘤坏死因子和白细胞介素6等则可能诱导胰岛素抵抗,这些因子表达的增强或减弱,可从不同层面影响胰岛素的生物学效应。脂肪组织源性激素之间的相互作用及其对血糖稳态的调节正成为一个新的研究热点。更多还原

【Abstract】 Adipose tissue has been identified as an active endocrine organ that not only stores energy and regulates nutrient homeostasis but also releases a large number of protein hormones(adipokines),which communicate with liver,skeletal muscle,and the brain thereby modulating hemostasis,blood pressure,lipid and glucose metabolism,inflammation,and atherosclerosis.It has been reported that some adipokines such as adiponectin,leptin,omentin,visfatin,vaspin associated with insulin sensitizer,however,other adipokines such as chemerin,resistin,retinol binding protein 4,tumor necrosis factor and interleukin-6 might induce insulin resistance.Increase or decreass in the expression of these adipokines would have effect on the biological effects of insulin at different levels.The interplay between adipose tissue-derived hormones as well as their effects on glucose homeostasis are becoming a new research focus.更多还原