【摘要】 过敏性紫癜(HSP)是儿童时期最常见的小血管炎性疾病。大部分经对症治疗后可恢复,但可出现严重并发症,如肾衰竭等。糖皮质激素可减轻腹部和关节疼痛的严重程度以及持续时间,但不能预防紫癜性肾炎的发展,或改变HSP的自然病程。目前,对于严重紫癜性肾炎最有效的治疗方案仍不清楚。进一步研究以明确HSP遗传易感性和发病机制非常有必要。更多还原

【Abstract】 Henoch-Schnlein purpura(HSP)is the most common vasculitis of childhood.Most cases resolve with symptomatic treatment,but serious complications can occur such as renal failure.Corticosteroid therapy reduces the duration and severity of abdominal and joint pain,but corticosteroids do not prevent the development of nephritis,or alter the natural history of HSP.The most effective treatment for severe nephritis remains unclear.Further research is necessary in order to clearly define the genetic susceptibility and the pathogenesis of HSP.更多还原