【摘要】 目的观察新一代铂类化疗药洛铂+氟尿嘧啶同步放疗治疗中晚期食管癌的有效性和安全性。方法 2006年10月至2007年12月收治的40例经病理证实为鳞癌的中晚期食管癌患者入组。全部患者采用6MV-X线常规分割放射治疗,总剂量为60~66 Gy,2 Gy次/,每周5次。化疗在放疗的第1天开始,方案为洛铂30 mg/m2,静脉滴注d1,氟尿嘧啶500 mg/m2,静脉滴注d1~5;按WHO评价标准评定疗效和不良反应。结果 40例患者全部可评价疗效,获得完全缓解15例,部分缓解20例,稳定3例,进展2例,有效率为87.5%。主要不良反应表现为急性放射性食管炎、骨髓抑制、消化道反应,3/4度少见,未见明显肝肾毒性。结论洛铂+氟尿嘧啶化疗联合放疗是一种安全、有效的治疗中晚期食管癌的方法,值得临床进一步研究。更多还原

【Abstract】 Objective To observe the efficacy and safety of lobaplatin+fluorouracil,with concurrent radiotherapy in treatment of advance esophageal carcinoma.Methods From October 2006 to December 2007,40 patients with advance esophageal carcinoma were enrolled.All of the patients were treated with conventional fractionated radiotherapy using 6MV X-ray with the dose of 2 Gy once a day,5 times per week,the total dose was 60-66Gy.The chemotherapy consisted of 2 cycles of Lobaplatin(30mg/m2,d1)and fluorouracil(500mg/m2,d1-5)every 4 weeks.Toxicity evaluated according to WHO criteria.Results All of the patients were evaluatable for recent objective,15 patients achieved complete remission,20 patients achieved partial remission,3 stable and 2 progress.The overall response was 87.5%.The major toxicities were acute radiation-induced esophagitis,myelosuppression and gastrointestinal tract reaction.The incidence rate of grade 3/4 toxicities was low.No obvious renal and hepatic function toxicities were observed.Conclusion Lobaplatin and fluorouracil combined with radiotherapy is effective and well tolerated in treatment of advance esophageal carcinoma.Further clinical study on this regimen is worthwhile.更多还原