【摘要】 前列腺癌是男性泌尿生殖系统常见的恶性肿瘤。前列腺癌是一种雄激素依赖性恶性肿瘤,经抗雄激素治疗后部分患者病情好转,但部分患者在治疗12～18个月后逐渐对抗雄激素治疗失去反应,逐步发展为雄激素非依赖性前列腺癌。因此,揭示其发生机制是预防和治疗雄激素非依赖性前列腺癌的关键。近年来,对雄激素非依赖性前列腺癌的发生机制有了许多新的认识和进展。更多还原

【Abstract】 Prostate cancer(PCa)is a common malignant tumor of male genitourinary tract and also an androgen-dependent maligant tumor.The majority of PCa patients recover following the androgen antagonist treatment,whereas some patients do not respond to androgen antagonist 12-18 months following the treatment,in whom PCa progresses into androgen-independent PCa.Therefore,the investigation into the pathogenesis of androgen-independent PCa is critical for the prevention and treatment of androgen-independent PCa.Some new knowledge and progress have been in place in the sense of mechanisms of actions of androgen-independent PCa.更多还原