【摘要】 乳腺叶状肿瘤(PT)是一组与纤维腺瘤(FA)类似的局限性双相性肿瘤。目前在临床诊断上面临的问题主要有两个方面:一是没有明确的标准将其与FA相区分;二是对于不同恶化程度的PT的界定还比较困难,只能采取局部扩大切除治疗。解决上述问题的关键是需要找到区分FA和PT,以及不同分化程度的PT的特异标志物,仅靠传统的影像学和细胞学检查难以做到。免疫组织化学结合现代分子生物学技术筛选到了多个相关的生物学标志物,为PT的诊断提供了强有力的依据。更多还原

【Abstract】 Phyllodes tumor(PT)of the breast is a kind of limited and diphasic tumor,which is similar to fibroadenoma.There are two major problems we are facing therapeutically:one that makes a distinction between PT and fibroadenoma(FA),the other is to differentiate phyllodes tumor grades.The key to resolve problems described above is finding biomarkers between PT and FA,also between different PT grades,which can not achieve just depend on traditional iconography and cytology examination.Many biomarkers have been found through immunohistochemistry combined with modern molecule biotechnology that lay a foundation of PT diagnosis and therapy.This article reviews advanced researches of PT related biomarkers.更多还原