【摘要】 目的观察不同麻醉方式围术期对血浆趋化因子GRO-1、IP-10的变化,研究不同麻醉方式围术期对腹腔镜下子宫次切术患者免疫功能和肿瘤转移的影响。方法选择ASAⅠ～Ⅱ级腹腔镜下子宫次切术患者60例,随机分为3组:全凭静脉麻醉组(A组),静吸复合麻醉组(B组),全麻联合硬膜外阻滞组(C组),每组各20例。在麻醉前(T0)、术毕(T1)、术后24h(T2)、术后48h(T3)和出院前2h(T4)观察各时点MAP、HR、RR、SpO2,采集外周静脉血测定趋化因子GRO-1、IP-10浓度。结果患者血浆GRO-1、IP-10浓度术后均有不同程度的降低,其中B组T1时较A、C组降低更加明显;3组各时点间差异均无显著性意义。结论不同麻醉方式对围术期腹腔镜下子宫次切术患者免疫功能和肿瘤转移的影响无显著性差异,均可安全应用于腹腔镜下子宫次切术患者的麻醉。更多还原

【Abstract】 Objective To select different anesthesia mode during perioperative laparoscopic hysterectomy and to assess the concentration of GRO-1 and IP-10 in plasma and to investigate the influence on the paitents’ immune function and tumor metastasis.MethodsThe sixty paitents belonging to ASA Ⅰ～Ⅱ who will accept the laparoscopic hysterectomy were averagely divided into 3 groups at random:total intravenous anesthesia(A group),intravenous combined with inhalation anesthesia(B group),general anesthesia combined with epidural block(C group).There were four observation points:before anesthesia(T0),after operation(T1),twenty four hours after operation(T2),forty eight hours after operation(T3),two hours before discharge(T4).At each point,we would observe the change of the MAP,HR,RR,SpO2 and collect the perpheral blood for measuring the concentration of Chemokines GRO-1 and IP-10 in plasma.Results The concentration of GRO-1 and IP-10 in plasma was decreased after operation,while the results at T1 point in B group were significantly lower than those of A and C group.The difference of each point among groups had no statistical significance.Conclusion The different anesthesia mode during perioperative laparoscopic hysterectomy has no statistical significance to the paitents’ immune function and tumor metastasis,so they can be safely used.更多还原