【摘要】 目的探讨结直肠癌患者血清中可溶性CD44V9的表达和临床意义。方法应用ELISA法检测比较27例结直肠癌患者、13例结肠腺瘤患者、20例正常人血清中的可溶性CD44V9的水平。结果结直肠癌患者血清中的可溶性CD44V9水平高于正常对照组,P=0.012;腺瘤组与正常对照组无显著性差异,P=0.108。伴有远处转移的Ⅲ、Ⅳ期结直肠癌患者血清中可溶性CD44v9水平高于没有远处转移的Ⅰ、Ⅱ结直肠癌患者,P=0.015。低分化、黏液腺癌的结直肠癌患者血清中可溶性CD44v9水平明显高于高中分化的结直肠癌患者,P=0.018。结论血清中可溶性CD44V9是一种结直肠癌的诊断、有无转移及预后的较好指标。更多还原

【Abstract】 Objective To discuss the expression of serum soluble CD44V9 in the patients with Colorectal Carinoma and its significiance.Methods The levels of soluble CD44V9 were determined by ELISA in 27 cases of colorectal carcinoma,13 cases of colonic adenoma,and 20 cases of healthy controls.Results Serum soluble CD44V9 of colorectal carcinoma was much higher than of healthy control(P=0.012).Serum soluble CD44V9 of colonic adenoma was not significantly different from healthy controls(P=0.108).Conclusion The level of serum soluble CD44V9 is a good target in diagnosis,transfer judgernent and prognosis predicting of the patients with colorectal carcinoma.更多还原