【摘要】 心律失常与多种心血管疾病的发生发展有关,并与心源性猝死密切相关。研究心律失常的分子机制及其可能的治疗手段具有重要意义。microRNA与心脏多种离子通道蛋白表达以及心律失常的发生有紧密关系。同时,microRNA干扰技术的发展和应用为心律失常的生物或基因治疗奠定了基础。更多还原

【Abstract】 Arrhythmias are often accompanied with multiple cardiovascular diseases and highly associated with cardiac sudden death. It is significant to investigate the underlying molecular mechanisms and potential therapeutic strategy for arrhythmias. Lines of recent studies show that microRNAs are closely correlated to the expression of various ion channel proteins in cardiomyocytes and the incidence of the arrhythmias. Meanwhile, the development and application of microRNA interference technologies have established the foundation for microRNA-based therapy.更多还原