【摘要】 可逆的蛋白磷酸化调控多种生化反应。蛋白磷酸酶是结核分枝杆菌的关键分子,不仅调控许多微生物自身的代谢,而且还可能干扰宿主细胞的信号传导。在结核分枝杆菌逃避宿主细胞的杀灭、阻止吞噬体与溶酶体融合中蛋白磷酸酶也起着重要的作用。选择性抑制这些信号途径可能是抗结核药物研发的新思路。本文综述了结核分枝杆菌蛋白磷酸酶MptpA、MptpB、MstP、SapM及其底物、磷酸酶表达调控基因和网络、抑制剂研发进展,以期为新抗生素靶标提供信息。更多还原

【Abstract】 Reversible protein phosphorylation regulates multiple biochemical events.Mycobacterium tuberculosis phosphatases play important roles in regulating the pathogen physiology and interference of host signaling.They are also involved in the evasion of host immune response and blockage of the phagosome-lysosome fusion.Selective inhibition of phosphatase represents an ideal new avenue of anti-tuberculosis drug design.In this paper,we update the progresses about the regulation network of Mycobacterium tuberculosis phosphatases including MptpA,MptpB,MstP,SapM and their inhibitors.These serve as the basis for further anti-tuberculosis drug target.更多还原