【摘要】 血脂康胶囊(红曲醇提取物)是北京北大维信生物科技有限公司自主研究的特制红曲霉发酵制成的调脂中药。通过血脂康调整血脂的临床观察,发现血脂康可降低各种冠心病相关事件的危险性及各种死亡率。为了解释血脂康的许多临床表现,对血脂康进行系统的成分研究。通过成分分析研究,从血脂康中分离纯化了一个新的莫纳克林类化合物,命名为α,β-dehydromonacolin L(1)及两个已知的莫纳克类化合物monacolin L(2)和3-(2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)propanoic acid(3)。结合核磁共振和质谱分析确定了化合物的化学结构。更多还原

【Abstract】 Xuezhikang capsule(ethanol extract of red yeast rice) which produced by Beijing WBL Peking University Biotech Co.,Ltd.,is a traditional Chinese medication with 3-hydroxy-3-methylglutaryl-coenzyme A(HMG-CoA) reductase inhibiting activity.Clinical trials indicated that Xuezhikang with lipid-lowering action could reduce the risk of cardiac events and total mortality of Chinese coronary heart disease patients.To exactly explain the clinical features of Xuezhikang,we undertook a complete study of the chemical constituents of Xuezhikang.This study resulted in the isolation of a new monacolin analogue,named α,β-dehydromonacolin L(1),along with two known compounds:monacolin L(2) and 3-(2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)propanoic acid(3).The chemical structures were determined by extensive 1D and 2D NMR and MS spectroscopic analysis.更多还原