【摘要】 目的:探讨幼年类风湿关节炎外周血中凋亡因子Fas、Fas L表达情况。方法:应用流式细胞仪检测对照组、JRA组活动期及非活动期Fas、Fas L的表达水平。结果:JRA组Fas、Fas L明显高于对照组(P<0.001),活动期Fas、Fas L明显高于非活动期(P<0.01)。结论:JRA患儿外周血中Fas/Fas L表达异常,病变活动期高于非活动期。为生物学治疗提供了理论依据。更多还原

【Abstract】 Objective:To explore Fas and Fas L’s expression in peripheral blood.Methods:To detect Fas and Fas L’s expression level in the control group,activity group and non-activity group by FCM.Results:Fas and Fas L in JRA group was higher than the control group significantly(P<0.01).The Fas and Fas L’s expression level in activity group was higher than the non-activity significantly(P<0.01).Conclusion:The JRA patient expression level of Fas/Fas L was abnormal in peripheral blood,the expression in activity was higher than non-activity.This study provides a basis for Biological therapy.更多还原