【摘要】 西罗莫司(sirolimus)又名雷帕霉素(rapamycin)是一种大环内酯抗生素,目前作为免疫抑制剂已在临床上广泛使用。作为国内外研究的热点,研究发现西罗莫司具有抗炎、免疫调节、抗肿瘤、抗动脉粥样硬化、抗衰老和神经保护等多种生物活性。本文综述了其近十多年来西罗莫司药理学作用的研究进展,并对其发展前景做了展望。更多还原

【Abstract】 Sirolimus,a kind of macrolide antibiotics,was widely used in clinical as immunosuppressive agents.In recently research,it had been found that sirolimus had potent biologic activities in terms of anti-inflammatory,immunosuppression,anti-neoplasms,anti-atherosclerosis,anti-aging,neuroprotection and so on.The progress pharmacological effects in the past ten years and forecaesd and the development prospects of sirolimus were reviewed in this paper.更多还原