【摘要】 目的评价Ⅰb￣Ⅱa期大菜花型宫颈癌于根治术前介入及化疗的疗效及安全性。方法 60例Ⅰb￣Ⅱa期大菜花型宫颈癌患者,采用以顺铂为主动脉灌注给药术前介入及化疗结束后2周￣3周内行子宫广泛切除术及盆腔淋巴清扫术。结果 60例患者共行介入化疗78次,C R 16例,PR 36例,N R 8例,总有效率为86.7%.52例手术患者中,6例Ⅱa期患者术后病理证实有盆腔淋巴结转移者术后追加放射治疗。手术病例中未出现手术并发症,手术时间平均(4.12±1.02)h,术中出血量平均(310.6±58.5)m L.结论Ⅰb￣Ⅱa期大菜花型宫颈癌在根治术前给予动脉灌注化疗能使肿瘤缩小,宫旁组织浸润消退,且术中出血较少,可为根治性手术创造条件。更多还原

【Abstract】 Objective To evaluate efficacy and safety of preoperative intervention and chemotherapy in the Phase Ⅰb~Ⅱa large cauliflower-type cervical cancer.Methods 60 cases ofⅠb~Ⅱa patients with large cauliflower-type cervical cancer,using cisplatin as the aortic perfusion chemotherapy administered preoperative chemotherapy intervention and 2~3 weeks after the wide excision experts uterus and pelvic lymph node dissection.Results Of the 60 patients a total of 78 interventional chemotherapy CR 16 cases,PR 36 cases,NR 8 cases,the total effective rate was 86.7%,52 cases of surgical patients,6 cases of patients with Ⅱa pathologically confirmed pelvic lymph node metastasis additional postoperative radiation therapy;surgical complications does not appear,surgery an average of(4.12 ± 1.02)h,the average blood loss(310.6 ± 58.5)mL.Conclusion Ⅰb~Ⅱa view to large cauliflower-type cervical cancer in the preoperative intra-arterial infusion chemotherapy for cancer can Uterine tissue infiltration subsided,and less bleeding,which create the conditions for radical surgery.更多还原