【摘要】 MicroRNAs(miRNAs)是一类单链小分子非编码RNA,通过结合靶基因mRNA的3′非翻译区从而抑制mRNA表达。目前发现miRNAs不仅参与生命过程的一些重要进程,也与许多疾病的发生和发展密切相关。本文综合近年文献,对缺血性脑卒中这一病理状态下的动物和病人的脑组织及血液miRNAs的表达及其作用做一综述。更多还原

【Abstract】 MicroRNAs(miRNAs) are small,non-protein-encoding RNAs that post-transcriptionally regulate gene expression via suppressing the specific target mRNAs.MiRNAs are also known to play important roles in many physiological and pathological processes.In this article,the expressions of miRNAs in both brain and blood of animals and patients with ischemia stroke are reviewed.更多还原