【摘要】 目的:观察济泰片对吗啡损伤小鼠免疫功能的影响。方法:皮下注射(sc)吗啡建立吗啡依赖小鼠模型。称量胸腺、脾脏重量。采用碳粒廓清实验,二硝基氟苯(DNFB)诱导小鼠迟发性变态反应(DTH)实验和血清溶血素测定,观察济泰片对吗啡损伤小鼠免疫器官指数、非特异性和特异性免疫功能的影响。结果:济泰片0.30 g(原粉).kg-1和0.60 g(原粉).kg-1能显著升高吗啡损伤小鼠廓清指数(K)和吞噬指数(α)(P<0.05,P<0.01),耳肿胀度(P<0.01)和半数溶血值(HC50),并且能显著抑制免疫器官的萎缩。结论:济泰片能显著增强吗啡损伤小鼠的免疫功能。更多还原

【Abstract】 Objective:To observe the effects of Jitai tablets on immune function in morphine dependent mice.Methods:A chronic morphine dependent model was established by repeated subcutaneous injection of morphine in mice.Thymus and spleen index were determined.Carbon clearance test,dinitrofluorobenzene-induced delayed type hypersensitivity test(DTH) and hemolysin test were employed to evaluate the immunomodulating effects of Jitai tablets in morphine dependent mice.Results:Jitai tablets(0.30 g·kg-1 and 0.60 g·kg-1) significantly increased clearance index(K),phagocytic index(α),ear swelling,hemolysin level(HC50 value) as well as thymus and spleen index in morphine dependent mice(P<0.01).Conclusion:Jitai tablets can significantly enhance the immune function of morphine dependent mice.更多还原