【摘要】 目的了解我院儿童药品不良反应的发生情况,探讨儿科药品不良反应产生的原因和影响因素。方法对我院小儿内科及小儿外科医务人员自愿呈报的229例不良反应报告进行回顾性分析。结果 229例不良反应涉及的可疑药品共计266种。其中抗感染药物为170例次,其次为中药注射剂25例次。抗感染药物中抗生素所占的百分比为61.65%,第三代头孢菌素达到55例次。静脉给药途径是发生不良反应最多的给药途径。61.99%的患者出现了皮肤及其附件的损害。229例不良反应停用可疑药物或给予相应治疗措施后,167例患者治愈,62例患者好转。结论儿童ADR的发生与单次药物剂量过大、滴注速度过快等因素有关,临床需合理用药,减少不良反应的发生。更多还原

【Abstract】 Objective To investigate the adverse drug reaction(ADR) on children in our hospital,and explore the related factors.Methods Retrospective analyses of ADR were performed on the children cases voluntarily submitted by the medical staff of pediatrics in our hospital.Results A total of 266 suspected medicines were involved in 229 ADR cases,among which 170 cases of anti-infective drugs followed by 25 cases of traditional Chinese medicine injection.61.65% of anti-infective drugs were antibiotics,and 55 cases were the third generation cephalosporin.Intravenous route was the most common routes for ADR.Skin and appendages damage were observed in 66.9% of cases.167 patients were cured and 62 cases were improved after drug was withdrawn or receiving the appropriate treatment.Conclusion ADRs were related to many factors,and rational use of drugs was needed to reduce the incidence of ADR.更多还原