【摘要】 在牙齿发育过程中,当牙冠发育完成后,上皮根鞘的形成启动了牙根发育,然而关于牙根发育启动的分子调控机制目前尚未明了。该文就近年来关于牙根发育启动的信号通路,主要包括Shh信号通路、TGF-β信号通路、Nfic家族、成纤维细胞生长因子家族以及Notch信号通路等的研究进展作一综述。更多还原

【Abstract】 The tooth root begins its development once the basic architecture of the crown has been established.Root development is characterized by cellular proliferation of the external and internal enamel epithelia known as Hertwig’s epithelial root sheath(HERS).It has been shown that Hertwig’s epithelial root sheath is very important for tooth root development,but the molecular mechanisms are still unclear.Recent progresses,including Shh signal pathway,TGF-β signal pathway,Nfic signal pathway,the fibroblast growth factor family and Notch signal pathway,are reviewed in the article.更多还原