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中西医结合治疗糖尿病肾病疗效的系统评价

The Effect of Combined Treatment of Chinese Medicine and Western Medicine on Diabetic Nephropathy:A Meta-analysis

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【作者】 张嬿叶学锋沈伟涂翔罗梅

【Author】 ZHANG Yan,YE Xue-feng,SHEN wei,TU Xiang,LUO Mei(Teaching and Research Section of Western Medicine,School of Clinical Medicine/The affiliated Hospital,Chengdu University of Traditional Chinese Medicine,Chengdu Sichuan 610075,China)

【机构】 成都中医药大学附属医院/临床医学院

【摘要】 目的:运用循证医学的方法,评价中西医结合治疗糖尿病肾病(DN)的疗效。方法:收集中西医结合与单纯西医药治疗DN的随机对照试验(RCT)和半随机对照试验(CCT),评价纳入试验的质量,采用Revman4.2.2软件进行Meta分析。结果:纳入69篇RCT和1篇CCT,全部论文被评为C级。Meta分析结果显示:与单纯西医药治疗相比,中西医结合治疗可进一步减少DN的尿白蛋白排泄率、24h尿白蛋白排泄量、24h尿蛋白定量、尿素氮、血清肌酐,提高内生肌酐清除率和总有效率。结论:中西医结合治疗优于单纯西医药治疗,但由于本系统评价所纳入研究存在方法学上的缺陷,加之评价的主要是DN相关的实验室指标,而非终点指标,所以中西医结合治疗DN的疗效尚需进一步研究。

【Abstract】 Objective:To assess the effect of combined treatment of Chinese medicine and western medicine on diabetic nephropathy(DN).Methods:Randomized or semi-randomized controlled trials(RCT or CCT) which compared combined treatment of Chinese medicine and western medicine with western medicine alone were collected.The methodological qualities of included studies were evaluated and meta-analysis was performed.Results:69 Chinese RCTs and 1 CCT were included in this review.All trials were classified as grade C.The results of meta-analysis demonstrated that compared with western medicine alone,combination with Chinese medicine could significantly decrease the urinary albumin excretion rate,the 24-hour urinary albumin excretion,the 24-hour urinary protein excretion,blood urea nitrogen and serum.

  • 【文献出处】 云南中医学院学报 ,Journal of Yunnan University of Traditional Chinese Medicine , 编辑部邮箱 ,2011年04期
  • 【分类号】R587.2
  • 【被引频次】25
  • 【下载频次】472
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