【摘要】 目的:评价术前使用氟比洛芬酯对术后镇痛的有效性和安全性。方法:按设定的检索方法全面检索万方、维普数据库,根据研究的纳入标准在267篇文献中筛出15篇有效文献,应用Rev-Man 5.0软件对文献中术后4 h、24 h两个时间点的视觉模拟评分法(Visual Analogue Score,VAS)评分进行Meta分析。结果:15篇文献研究的异质性检验显示试验结果的差异有统计学意义(P<0.05);选择随机效应模型进行分析,Meta森林图分析结果显示:术后4 h、24 h的VAS评分合并效应量的检验均具有统计学意义,认为氟比洛芬酯组较空白对照组的镇痛效果有差异(P<0.05);不良反应例数的合并效应量的检验不具有统计学意义,尚不能认为氟比洛芬酯组与空白对照组的不良反应有差异(P>0.05)。结论:现有的临床文献数据表明,术前使用氟比洛芬酯能有效降低患者术后疼痛,尚不能认为能降低术后不良反应发生率。更多还原

【Abstract】 AIM: Meta analysis of preoperative use of flurbiprofen on postoperative analgesia efficacy and safety.METHODS: 15 articles were sieved into the pump out of according to set a comprehensive search of the database search methods and research into the proposed standard from 267 documents,applications RevMan 5.0 software into the pump after the literature 4 h,24 h two time points Meta-analysis of VAS score.RESULTS:15 articles of the heterogeneity test showed the results of trials was significantly(P<0.05),select the random effects model analysis.Meta analysis showed that the forest plan: post-operative 4 h,24 h of VAS combined effect of the amount of test score were statistically significant in analgesic effect between flurbiprofen group and control group(P<0.05).The number of patients in the combined adverse effects of the amount of testing was not statistically significant,still could not believe that flurbiprofen group and control group differences in adverse reactions.CONCLUSION: The available clinical data indicate that preoperative use of flurbiprofen can reduce postoperative pain,patients still can not believe that could reduce the incidence of adverse reactions.更多还原