【摘要】 目的:观察静脉使用右美托嘧啶对硬膜外麻醉下阑尾手术牵拉反应的预防效果。方法:选择在硬膜外阻滞下进行阑尾切除术的患者80例,美国麻醉医师协会评级Ⅰ～Ⅱ,随机分为右美托嘧啶组与生理盐水对照组(对照组)每组40例。在切皮前10 min分别从静脉泵注1μg/kg右美托嘧啶和相同剂量的生理盐水,输注时间均为10 min,观察术中患者对牵拉阑尾的反应、用药前后血流动力学、呼吸及Ramsay镇静分级情况。结果:右美托嘧啶组中阑尾手术牵拉反应明显降低,其优良率明显高于对照组(P<0.01),但右美托嘧啶组中心率在5、10和15 min明显低于对照组(P<0.01),右美托嘧啶组在用药后10、15和30 min时的Ramsay镇静分级明显高于对照组(P<0.01)。结论:静脉给予1μg/kg右美托嘧啶能有效预防硬膜外麻醉下阑尾手术牵拉反应。更多还原

【Abstract】 AIM: To evaluate the efficacy of epidural anesthesia versus intravenous dexmedetomidine on visceral traction response during appendectomy. METHODS: Eighty adult patients,American Society of Anesthesiology(ASA) physical status class Ⅰ-Ⅱ,undergoing appendectomy during epidural anesthesia were divided randomly into two groups that received 1 μg/kg dexmedetomidine(Dexmedetomidine Group) and the same volume normal saline(Control Group) intravenously for 10 min respectively.The visceral traction response of the patients,the changes of the MAP,HR and SpO2,and the grade of Ramsay before and after dexmedetomidine or the normal saline was administered were evaluated during the operation.RESULTS:Intravenous dexmedetomidine could inhibit the visceral traction response during appendectomy,was superior to normal saline(P<0.01).The changes of MAP and SpO2 in the two groups were not different,but HR was decreased significantly in Dexmedetomidine Group(P<0.01),the grades of Rassmay were increased significantly in Dexmedetomidine Group(P<0.01).CONCLUSION: Intravenous dexmedetomidine could inhibit the visceral traction response effectively during appendectomy.更多还原