【摘要】 目的:观察地佐辛注射液应用于鼻内镜手术时对患者围拔管期血流动力学稳定及苏醒时效的影响。方法:选择ASAⅠ～Ⅱ级鼻内镜手术病例60例,随机均分为3组:Ⅰ组(地佐辛组,男11例,女9例)、Ⅱ组(芬太尼组,男12例,女8例)、Ⅲ组(对照组,男9例,女11例)。三组病人均用咪达唑仑+异丙酚+舒芬太尼+顺式阿曲库铵静脉诱导后行气管插管,术中以吸入七氟醚和持续静注异丙酚麻醉。术毕填塞纱布条时,Ⅰ组以地佐辛0.1 mg/kg,Ⅱ组以芬太尼0.002 mg/kg,Ⅲ组以生理盐水1 mL静脉注射,观察围拔管期血流动力学相关指标及苏醒时效。结果:三组病人术后苏醒及拔管时间无统计学差异;围拔管期血流动力学Ⅰ组、Ⅱ组较Ⅲ组稳定,差异有统计学意义(P<0.05)。结论:地佐辛组拔管时循环动力学稳定、镇静适度,对苏醒时间无影响,地佐辛用于鼻内镜手术围拔管期安全有效,麻醉苏醒过程平稳。更多还原

【Abstract】 AIM: To explore the effect of hemodynamics and emergence time when dezocine is used in the periextubation period of endoscopic sinus surgery. METHODS: 60 patients treated with endoscopic sinussurgery were divided into three groups randomly,the group Ⅰ,including 11 men and 9 women,were injected with dezocine 0.1 mg/kg,and the group Ⅱ(12 men and 8 women) was injected with Fentanyl 0.002 mg/kg,and the group Ⅲ,including 9 men and 11 women,was injected with normal saline 1 mL when the surgery is over.The index of bloodstream dynamics stable and limitation to wake among the three groups was observed.The patients were induced tracheal intubation by intravenous injected midazolam,propofol,and cisatracurium.Sevoflurane was inhaled and the propofol was intravenous injected during operation.RESULTS:The emergence time among the three groups had no statistics difference(P>0.05).Compared with the group Ⅰ and group Ⅱ,the hemodynamics in the periextubation period of endoscopic sinus surgery was stable in the group Ⅲ,there was significant difference(P<0.05).CONCLUSION: The circulatory dynamics is stable during extubation in the group Ⅰ,and there is no effect on emergence time.The dezocine is effective and safe when using at the the periextubation period of endoscopic sinus surgery.更多还原