【摘要】 2型糖尿病是我国主要慢性疾病之一,而其控制状况不容乐观。降糖药物的使用是控制血糖的重要利器之一,糖尿病的药物治疗按作用机制和结构主要分为胰岛素促泌剂、双胍类、噻唑烷二酮类药物、糖苷酶抑制剂、DPP-Ⅳ抑制剂、GLP-1、胰岛素及其类似物等。本文概述临床常用降糖药物的药理机制、作用特点及其特性,并提出适时启用胰岛素、简单化原则、合理联用、个体化原则及兼顾安全性、性价比的合理使用降糖药物策略。更多还原

【Abstract】 Type 2 diabetes mellitus is one of major chronic diseases in China,and its control is not optimistic.Antidiabetic drugs application is an important tool for the control of blood glucose.Diabetes medications by action mechanism and structure is divided into insulin secretagogues,biguanides,thiazolidinediones,glucosidase inhibitors,DPP-Ⅳ inhibitor,GLP-1,insulin and its analogs,etc.This paper overviews the clinical pharmacology mechanisms,characteristics and properties of commonly used antidiabetic drugs,and proposes the strategy of rational antidiabetic drugs application in type 2 diabetes mellitus,such as using insulin timely,simplicity principle,reasonable combination,individual principle and taking into account safety,cost.更多还原