【摘要】 目的:观察国产及进口肺表面活性物质(pul monary surfactant,PS)治疗新生儿呼吸窘迫综合征(neonatal respiratory distress syndrome,NRDS)的疗效。方法:将54例NRDS患儿随机分为珂立苏组(28例)和固尔舒组(26例),两组在常规治疗的同时,分别给予珂立苏与固尔舒气管内滴注观察两组的疗效。结果:用药前两组患儿均有严重低氧血症,用药后30 min两组患儿动脉-肺泡氧分压比值(a/APO2)和PaO2/Fi O2明显上升,换气功能改善,用药72 min后呼吸机参数下调。两种药物都可明显缩短机械通气的时间。结论:国产及进口PS治疗NRDS疗效相当,无明显差异。更多还原

【Abstract】 AIM: To compare the curative effects between domestic and imported pulmonary surfactant on neonatal respiratory distress syndrome(NRDS).METHODS: 54 neonates with NRDS were randomly divided into Calsurf group(domestic pulmonary surfactant,28 cases) and Curosurf group(imported pulmonary surfactant 26 cases).At the basic of conventional therapy,the two groups received domestic or imported pulmonary surfactant with single dose by intratracheal administration,respectively.The curative effects and adverse reaction were observed.RESULTS:Before using these drugs,the patients in two groups were all with hypoxemia,the artery-alveolar pressure ratio(a/APO2) and PaO2/FiO2 were increased significantly after 30 minutes.The gas exchange function was improved;the breathing machine parameters were lowered 72 minutes later.Two drugs could significantly reduce mechanical ventilation of time and improve the success rate of treatment.CONCLUSION: Both the domestic and imported pulmonary surfactant have the same good curative effects and safety on neonatal NRDS.更多还原