【摘要】 目的评价血液中高敏感性C-反应蛋白(high sensitivity C-reactive protein,hs-CRP)含量,作为下肢深静脉血栓形成的生物学观察指标的可行性。方法⑴动物实验研究:取实验犬8条,于左后肢大腿内侧切开皮肤,显露髂-股静脉1段,长3cm(deep vein thrombosis,DVT段),阻断血流后,注入血凝酶。24h,作患肢顺行静脉造影和彩超检查,确定DVT已形成,与术后每周重复影像学检查,并测定血液中高敏感C-反应蛋白含量,共计6周。⑵2006年1月-2011年1月,共收治膝关节近侧单肢DVT患者102例,其中男性58例,女性44例;年龄24-86岁,平均59.64岁;左下肢79条,右下肢23条,都于发病1周内入院。住院后作抗栓治疗2-3周后出院。于入院时、住院期内和出院后4-6周,分别作静脉造影和彩超检查,并同时检测血液中hsCRP的浓度。结果动物实验显示,彩超能更早、更准确地说明血栓再通的情况;DVT的病情演进与hsCRP的升高和回落呈正相关变化。临床研究显示,69例DVT患者疗效满意,28例好转,5例无效。入院时,血hsCRP为92.90-5.16,平均为29.90±30.40mg/L。出院4周后,hsCRP为45.80-0.93mg/L,平均为7.12±11.40mg/L,hsCRP的升高的情况与DVT的严重程度呈正相关。治疗效果不佳者出院时hsCRP虽下降但仍显著高于正常者。结论血液中hsCRP含量的变化,与DVT的病情演进,呈正相关改变,因此hsCRP可作为DVT的生物学观察指标,引导治疗的全过程,提高疗效,造福患者。更多还原

【Abstract】 Objective To assess the possibility of C-reaction protein to be a biomarker for deep venous thrombosis of lower limb.Methods From January,2006,Jnauary to 2011,January the DVT moder was established on the ilicfemoral vein of the left hind leg of eight dogs,weighted 20-25kg,by infusion of thrombin and teauma of the vein wall.After surgery,the thrombotic segments were exercised with venography and duplex ultrasound,and the serum hsCRP was also tested every third after surgery for 4 weeks.From 2006,January to 2011,January patients were admitted with diagnosis of acute DVT fou lower limbs.They were treated mainly with urokinase and molecular weight heparin fou 2-3weeks.The assessment of venography,duplex ultrasound and serum hsCRP were performed immediately after admission every fifth day to 4 weeks after discharge.Results After medical therapy fou 2-3weeks,the cinical fetures prominently subsided in patients.Clinical studies show that,69 cases of patients with DVT results were satisfactory,28 patients get better,5 cases is invalid.At admission,the hsCRP was 29.90±30.40mg/L and it dropped to 7.12±11.40mg/L at 4 weeks after discharge.Conclussion The hsCRP was possiblly related to the sevetity of DVT.It may be used as the biomarker of DVT,in guiding the treatment of DVT.更多还原