【摘要】 目的比较地佐辛复合小剂量氯胺酮用于剖宫产术后自控静脉镇痛(PCIA)的临床效果。方法选择60例剖宫产手术患者随机分为两组,A组镇痛液采用生理盐水加地佐辛25mg、芬太尼0.4mg及氟哌利多5mg,共100ml;B组采用生理盐水加地佐辛25mg、氯胺酮150mg及氟哌利多5mg,共100ml。所有患者均予以持续泵入镇痛给药模式。设定负荷剂量为0.1ml/kg,单次给药剂量为0.05ml/kg,连续给药速度为0.04ml.kg-1.h-1,锁定时间为15min。手术将结束时,给负荷剂量,接着进行连续背景输注给药。结果两组VAS评分差异无统计学意义,恶心呕吐、皮肤瘙痒发生率B组明显低于A组(P<0.05)。两组患者均未发生呼吸抑制。结论地佐辛复合小剂量氯胺酮用于剖宫产术后静脉镇痛,效果确切、不良反应少。更多还原

【Abstract】 Objective To investigate the effects of patient-controlled intravenous analgesia(PCIA) by dezocine compound low-dose ketamine.Methods Sixty patients were divided into two groups at random.Group A was administered with 25mg of dezocine,0.4mg of fentanyl and 5mg of droperidol in 100ml of saline,and group B with 25mg of dezocine,150mg of ketamine and 5mg of droperidol in 100ml of saline.The loading dosage and maintained dosage were used as venous analgesia.The loading dose is 0.1ml/kg and bolus is 0.05ml/kg and continus rate is 0.04ml·kg-1·h-1.The locking time is 15min.Results There were no significant differences in visual ache simulation(VAS).Propotion of nausea and vomitting of group B is less than group A.There were no respiratory depression of both groups.Conclusion Dezocine compound low-dose ketamine might be used as an analgetic agent after cesarean section with good effect.更多还原