【摘要】 为了寻找新型高效低毒的农药先导化合物,通过N-吡啶基吡唑肟与2-氯-5-氯甲基吡啶的缩合反应,合成了一系列含吡啶环取代的吡唑肟醚类化合物.目标化合物的结构均经1H NMR,13C NMR和元素分析确证.初步生物活性试验结果表明,部分化合物具有一定的杀菌、杀虫和植物生长调节活性.如化合物5c在浓度为50μg/mL时对番茄早疫的抑制率为61.4%;化合物5j在浓度为50μg/mL时对花生褐斑的抑制率为60.2%;化合物5i在浓度为500μg/mL时对蚜虫表现出50.3%的杀死率;化合物5f在浓度为10μg/mL时对黄瓜子叶生根表现出71.0%的促进生长作用.更多还原

【Abstract】 In search of new low toxicity and potent pesticide lead compounds,a series of novel pyrazole oxime ether derivatives containing a pyridyl ring were synthesized by the condensation of N-pyridyl pyra-zole oximes with 2-chloro-5-chloromethyl pyridine.Their structures were determined by 1H NMR,13C NMR spectra and elemental analysis.Preliminary bioassay showed that some of the target compounds dis-played fungicidal,insecticidal,and plant growth regulatory activities to some extent.For example,com-pound 5c exhibited 61.4% inhibition rate against Alternaria solani at the concentration of 50 μg/mL,com-pound 5j showed 60.2% inhibition rate against Cercospora arachidicola at the concentration of 50 μg/mL,the mortality rate of compound 5i was 50.3% against Aphis craccivora at the concentration of 500 μg/mL,and compound 5f displayed 71.0% promotion effect on the radicle growth of cucumber cotyledons at the concentration of 10 μg/mL.更多还原