【摘要】 幽门螺杆菌(Helicobacter pylori)感染能导致慢性胃炎、消化性溃疡、胃粘膜相关的淋巴样组织(Mu-cosa-associated lymphoid tissue,MALT)淋巴瘤和胃腺癌等疾病的发生。1994年世界卫生组织国际癌症研究中心(IARC)将H.pylori列为胃癌第一级因子。H.pylori感染引起的不同临床结局主要与H.pylori致病因子和宿主遗传易感性有关,大部分重大疾病发生在特定的细菌毒力因子(如cagA,vacA)与易感宿主遗传背景共同存在时。文章综述了H.pylori菌株的毒力基因的分型和宿主的遗传多态性对胃病发生的影响。更多还原

【Abstract】 Helicobacter pylori infection may cause many gastric disease,such as peptic ulcers,chronic atrophic gastritis,gastric mucosa-associated lymphoid tissue lymphoma,and gastric cancer.The different clinical outcomes of Helicobacter pylori infection are related to H.pylori virulence factors and host gene polymorphism.H.pylori had been confirmed to be the class I carcinogen by the World Health Organization and International Agency for Research on Cancer Consensus Group(IARC) in1994.Most severe diseases always occur in the background that certain microbial virulence markers(e.g.cagA,vacA) and susceptible host genetic polymorphisms harboured together.Herein,we reviewed the association with H.py-lori-related gastric diseases in relation to diffirent H.pylori types and the host polymorphisms.更多还原