【摘要】 目的应用阿托伐他汀降低血脂水平,观察其对保护糖尿病肾病患者肾功能的作用。方法选择糖尿病肾病伴有高脂血症患者160例,随机分为治疗组82例和对照组78例。治疗组患者予阿托伐他汀控制血脂。慢性肾衰竭药物治疗方案两组相同。观察期限12个月,比较两组患者血脂与肾功能的差异。结果治疗组血脂比对照组明显下降(P<0.001),eGFR下降明显低于对照组(P<0.01)。结论糖尿病肾病患者通过降低血脂水平,可明显延缓肾衰竭的进展,应尽早降低血脂至正常水平。更多还原

【Abstract】 Objective To investigate the effect of atorvastatin in protecting the renal function in patients with diabetic nephropathy by reducing serum lipids.Methods 160 patients of diabetic nephropathy with hyperlipemia were divided into treatment group(n=82) and control group(n=78) randomly.Atorvastatin was taken in the treatment group.The drug treatment programs of chronic renal failure were the same in the two groups.At the observation period of 12 months,serum lipids and renal function were compared between the two groups.Results Serum lipids(P <0.001) and the fall of eGFR(P <0.01) in the treatment group were lower than those in the control group significantly.Conclusion Reducing serum lipids in patients with diabetic nephropathy can delay the progress of renal failure.Serum lipids shall be controlled to standard level as soon as possible.更多还原