【摘要】 目的分析前列地尔治疗急性百草枯中毒(PQ)肺损伤的疗效。方法将30例百草枯中毒患者随机分组分为治疗组15例和对照组15例,所有患者均接受序贯性血液净化(血浆置换+血液灌流+血液透析)联合综合治疗。对照组静脉注射甲泼尼龙;治疗组在对照组治疗基础上加用前列地尔。结果对照组40%患者有效,治疗组75%患者有效,两组间有效比例差异有统计学意义(P<0.05)。治疗组治疗后PaO2、PaCO2、PaO2/FiO2改善较对照组显著(P<0.05)。治疗组治疗后X线胸片提示肺损伤好转9例,显著多于对照组5例(P<0.05);死亡率两组无差异。结论前列地尔注射液可以显著改善动脉血气、呼吸参数,对急性PQ中毒肺损伤有积极的治疗作用。更多还原

【Abstract】 Objective To analyze the efficacy of alprostadil for treatment of pulmonary damage in acute paraquat poisoning.Methods 30 patients with paraquat poisoning were randomly divided into treatment group(n=15) and control group(n=15),all patients underwent sequential blood purification(plasma exchange + hemoperfusion + hemodialysis) combined with comprehensive treatment.The control group was intravenously infused methylprednisolone;the treatment group was treated based on the use of alprostadil.Results In the control group 40% patients were effective,in the treatment group 75% patients were effective,the effective ratio between the two groups was significant(P <0.05).After treatment,PaO2,PaCO2,PaO2/FiO2 improved significantly than the control group(P <0.05).After treatment,X-ray prompted improvement in 9 patients with acute pulmonary damage,which were significantly more than the control group(n=5,P <0.05);there was no difference in mortality.Conclusion Alprostadil injection can significantly improve arterial blood gas,respiratory parameters,which has a positive therapeutic effect on pulmonary damage in acute paraquat poisoning.更多还原